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The most plausible explanation resides in the time-additive effects of the dual mechanisms of weight loss with SGLT2is

It also slows down the rate at which food leaves the stomach, which can help people feel fuller for longer and reduce food intake

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In the SURMOUNT-1 clinical trial, patients lost significant weight, with dose-dependent results ranging from approximately 15% to 20% of body weight over 72 weeks

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This includes a family health history to check for an inherited cancer risk