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Gastrointestinal side effects like diarrhea affect up to 20% of semaglutide users during the first weeks of treatment

However, some patients do report irritability, which is most often related to indirect factors such as under-eating, blood sugar fluctuations, sleep disruption, or changes in reward signaling rather than the medication itself.This post explains the science behind these effects, identifies who may be more vulnerable, and outlines practical strategies clinicians and patients can use to reduce risk

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March 17, 2026