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GLP-1 receptors are extensively expressed in brain reward circuits, particularly mesolimbic and mesocortical pathways involved in addictive behaviors [193]

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Therefore, it is hypothesized that ghrelin synthesized within the hypothalamus, as opposed to gut-derived ghrelin, is the mediator of central orexigenic effects of ghrelin, although further research is needed 224

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Some patients with favorable genetic profiles lose significant weight at 1.0 mg, while others require 2.4 mg to see comparable resultsnot because of body size alone, but because of how their genetic makeup regulates appetite and metabolism