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Research demonstrates that postmenopausal women experience a 9% decrease in total 24-hour energy expenditure and a 30% reduction in spontaneous physical activity energy expenditure.[1] The metabolic consequences are profound: estrogen deficiency worsens insulin resistance, which is further exacerbated by the age-related increase in cortisol that promotes gluconeogenesis

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PMID 38304165

Adults with obesity who reported more intense tastes while receiving semaglutide or tirzepatide had a higher likelihood for increased satiety and decreased appetite and food cravings, according to a presenter

Retatrutide produces greater blood pressure reduction than semaglutide

Therefore, the management of obesity in patients with PWS is challenging and requires the cooperation of an experienced multidisciplinary team, including the nutritionist