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If those intentions translate into behavior, as many as four in ten adults could eventually be on a GLP-1 medication

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(28) The crude incidence rates of LLA were 6.1 per 10,000 person-years for GLP-1 receptor agonists, 1.5 for SGLT-2 inhibitors, 4.6 for DPP-4 inhibitors, and 1.9 for older agents

The receptors have adapted to the new baseline

However, modern research indicates that GCGR agonism increases thermogenesis and energy expenditure through the activation of futile cycles in the liver and potentially the recruitment of brown adipose tissue

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