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GLP-1 agonists (known as GLP-1 receptor agonists to those who study them) are drugs designed to mimic the GLP-1 that your body naturally produces, giving you an extra boost of this Im full hormone

Emerging medications like retatrutide may eventually surpass all current options, and the precise dosing comparisons between medications help clinicians optimize individual treatment plans

Patients with diabetes using insulin or sulfonylureas with GLP-1 agents have an increased risk of hypoglycemia and may need dose adjustments of these medications

Hypothalamic-pituitary-adrenal (HPA) axis and cortisol dysregulation The dysregulation of the HPA axis is a significant pathway linking depression with T2DM [70]

Jastreboff AM, Aronne LJ, Ahmad NN et al

However, there is currently no direct evidence confirming the neuropsychiatric effects of GLP1RA in humans, and high-quality randomized controlled trials (RCTs) are still lacking