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Then, for an additional four weeks, the main groups were resampled to include treatment (Semaglutide, SME, 40 g/kg), or CR, totaling four groups: Control, Model, Model+SME, Model+CR

Mitigating Side Effects Several strategies have proven effective for managing adverse events: Starting with lower doses (e.g., 0.5 mg) rather than higher doses Implementing gradual dose escalation with adequate time between increases Maintaining patients at current doses longer when side effects emerge Monitoring and providing supportive care for gastrointestinal symptoms[8] These approaches can significantly improve tolerability and adherence to the medication regimen

Enrollment was completed in March 2026

These two approaches were applied to produce visual representations of body size and shape in Surmount 1 average male and female participants (maximal-tolerated dose group) at baseline and after 72-weeks of tirzepatide treatment

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Most people notice weight loss within 2-3 months of starting treatment