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29 In a study involving 1,306 overweight or obese individuals receiving 2.4 mg of semaglutide, approximately 6% and 12% weight loss was observed at 12 and 28 weeks, respectively, and total fat mass decreased by approximately 20% after 56 weeks of treatment

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Back in 2010, the US Food and Drug Authority (FDA) concluded that increases in the incidence of carcinomas among rodents translated into a low risk for humans, because statistically significant increases occurred only at drug-exposure levels many times those anticipated in humans

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In a mouse model of non-alcoholic fatty liver disease-associated HCC (207), liraglutide prevented HCC progression by modulating blood glucose levels and ameliorating steatosis and inflammation in non-tumorous liver lesions