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Description
Regulatory authorities such as the FDA and the European Medicines Agency (EMA) currently view these risks as manageable with ongoing monitoring [138]

The 2023 phase 2 double-blind, randomized controlled trial evaluating a GLP-1/GIP/glucagon receptor triagonist (retatrutide) in patients with the disease of obesity reported 24.2% weight loss at 48 weeks with 12 mg retatrutide

This breakthrough allowed peptide drugs to be synthesized at mass scale, without needing to be harvested from animal pancreases, and gave birth to the biotechnology industry

PH, posterior hypothalamic nucleus

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Annual research review: Maternal antidepressant use during pregnancy and offspring neurodevelopmental problems - a critical review and recommendations for future research
Weight loss is likely to be less than with semaglutide or tirzepatide
