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Inhibition of the sodium-glucose co-transporter SGLT2 by canagliflozin ameliorates diet-induced obesity by increasing intra-adipose sympathetic innervation

This work was supported by the National Key Technology R&D Program of China (2017YFC0113901)

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The observed changes in total and LDL cholesterol during semaglutide treatment in our cohort were in line with a systematic review and meta-analysis addressing the efficacy and safety of GLP-1 RAs on body weight and cardiometabolic parameters in individuals with obesity and without diabetes and with a systematic review and meta-analysis of semaglutide 2.4 mg including the 2-year STEP 5 trial (40, 41)

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