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Overall, they found that participants who received semaglutide alongside lifestyle interventions had a mean weight loss of 14.9% from baseline, compared with a mean weight loss of 2.4% in the placebo group

pmid:36817869 4

They deprived the rats of alcohol for 9 days and then gave them semaglutide

There likely will be greater utilization of these agents in persons without DM by our primary care and cardiology colleagues as well as endocrinologists

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As a GLP-1 agonist, it mimics the action of incretin glucagon-like peptide-1, thus increasing insuli.n secretion in the body and decreasing blood sugar disposal