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Delayed gastric emptying may influence: Meal tolerance Frequency of eating Nausea severity Portion size But current evidence does not support clinically significant malabsorption solely due to gastric slowing

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Notably, GLP-1 significantly suppressed plasma pancreatic polypeptide concentrations following the first meal,68 but this effect diminished substantially after the second test meal,72 suggesting autonomic nervous system adaptation to continuous GLP-1 administration

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The single-agent approach reduces polypharmacy burden, simplifies adherence, and sidesteps the safety red flags of combining two appetite-suppressing drugs