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Compounded GLP-1 medications are formulated to closely mirror the FDA-approved versions in how they work and the benefits they provide, including appetite control, improved blood sugar levels, and effective weight loss

A 2012 meta-analysis published in the Journal of Ethnopharmacology reviewed 14 randomized trials involving berberine supplementation

However, the same reservations regarding conclusions to be drawn from such an analysis of the FDA Adverse Event Reporting System apply as discussed above regarding the findings of an increased reporting rate for pancreatitis, pancreatic carcinoma, and thyroid cancer with exenatide and sitagliptin

Because GLP-1 medications slow stomach emptying and influence appetite signals, its common for people to experience some digestive discomfort, especially when first starting treatment or increasing their dosage