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According to Sinha et al., tirzepatide has better efficacy compared to many glucose-lowering medications such as dulaglutide, glargine, semaglutide, and insulin degludec and placebo drugs [14]

SeekPeptides members access detailed medication guides, protocol comparisons, and expert-reviewed resources that help navigate these complex treatment landscapes with confidence

In November 2023, the rate of discontinuations due to medication availability peaked at 14.6%

The retail price of these medications over $1000 per month [57] creates substantial financial barriers for patients and healthcare systems

GLP-1 acts through a specific GLP-1 receptor (GLP-1R), principally expressed by cells of pancreatic islets but present also in many other target tissues, such as lung, stomach, intestine, kidney, heart, and brain tissues [14,15]

Are other dual-agonists in development as effective, and what factors (e.g., tolerability profile) may allow for competitive differentiation