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is between 2.3 and 10.3 people per 100,000 individuals per year, resulting in approximately 6,000 new NAION cases each year, making it the most common cause of acute optic neuropathy in patients over the age of 50

Discussion The GLP-1-based therapies usually utilize two strategies: 1) inhibition of dipeptidyl peptidase 4 (DPP-4) enzyme with specific inhibitors, such as sitagliptin / vildgliptin, in order to raises plasma levels of endogenous GLP-1 and GIP and 2) utilizing DPP-4 resistant GLP-1 receptor agonists, such as liraglutide / exenatide 44

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7 Similarly, a joint guideline by the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) recommends GLP-1RAs as second- or third-line therapy in patients with predominantly atherosclerotic cardiovascular disease, a compelling need to minimise hypoglycaemia or a need to promote weight loss