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There is a high degree of frustration when people are taking the time to administer medication and are not able to achieve the results they are expecting

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This relationship mirrors the synergy between surgery and systemic therapy in oncology, where one modality targets macro-level disease (anatomical and hormonal reset) while the other addresses micro-level adaptations (homeostatic resistance)

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doi: 10.1007/s00125-009-1643-x 87 XuQZhangXLiTShaoS