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The hyperglycemia-induced downregulation of GLP-1R is involved in NF-B activation and the subsequent inflammatory response in mesangial cells (Zhou et al., 2014)

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It helps in reducing food intake by signaling the brain to feel full and satisfied

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Conclusion Emerging evidence underscores the cardioprotective effects of GLP-1RAs, which make them potentially useful for different subpopulations of patients with cardiovascular diseases, including those with HFpEF