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The Cleveland Clinic notes that tolerance is individual, and some high-fiber or gas-producing foods can worsen GI symptoms on GLP-1s, especially during dose escalation, including foods like beans, cruciferous vegetables, and certain starchy produce

Mounjaro achieves approximately 21% body weight loss after one year at the highest dose, compared to about 8% with Rybelsus 14 mg

However, the additive effect on blood glucose and gastrointestinal motility requires discussion with your PlexusDx provider

non-enzymatic actions and the overall significance of DPP-4 for normal physiological regulation in humans and for the pathogenesis of metabolic disease are still largely unknown, targeting the catalytic activity has been harnessed pharmacologically, and DPP-4 inhibitors now play an important part in the therapy of T2DM
The pathogenesis of this disorder tends to be multifactorial, ranging from epigenetics to hormonal imbalances and dysregulations[27]

GLP-1 medications can be used in Crohn's disease, but require careful medical oversight