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Some patients benefit from lower-dose GLP-1 therapy to maintain weight loss without aggressive suppression, then transition off the medication before conception attempts

Areas of future research Future studies should focus on addressing these gaps

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A first unexpected finding was the manifested simptoms of NAFLD at 2 weeks post-PH in livers from mice treated with Fc-GLP-1 fed a MCD diet or HFD despite the marked improvements in liver histology already detected in those livers at the moment of the liver resection

It is a 39 amino-acid, single peptide, engineered from a GIP peptide backbone, conjugated to a C20 fatty di-acid moiety to enable albumin binding and extend its half-life [42]

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