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Whereas semaglutide has been reported to promote weight loss in NASH patients 25,74 , lanifibranor slightly increases body weight in NASH patients compared to placebo 26

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The survey data did not specify timeline to improvement

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The GLP-1R is rapidly internalized when activated by its cognate agonist 9 , but the effect of internalization and subsequent post-endocytic trafficking on overall GLP-1 responses is not clear