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Although EECs might sense nutrients via activation of specific GPCRs on the apical side, where they are in direct contact with the luminal environment, elegantly performed ex vivo and in vitro studies suggest that many nutrients, including fatty acids, may be detected on the basolateral surface 17,93,94

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For instance, in phase 2 trials of SEMA 2.4 g, a substantial reduction in placebo response was observed in composite endpoints of MASH and fibrosis