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The modulation of NF-B by GLP-1 RAs can be mediated by counteracting the changes in methylation levels of NF-B promotor region that were induced by high glucose levels (Scisciola et al., 2020)

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Reports of suicidal ideation appeared in postmarketing monitoring of GLP-1 agonist users, prompting investigations by European regulators

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The most popular example of these advancements is Ozempic, a GLP-based drug that surpassed its predecessors

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