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Direct administration of leptin in AD brains improves hippocampal memory and learning in transgenic mice (McGregor and Harvey 2018)

This introduces variability in pharmacodynamics, as GLP-1RA penetration into specific brain regions may differ based on sex, compound properties, and age (Borchers and Skibicka, 2025)

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Leblanc, Y., Berger, M., Seifert, A., Bihoreau, N

This glucose-dependent action reduces the risk of hypoglycaemia, though this risk increases when tirzepatide is used in combination with insulin or sulfonylureas