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Conclusions GLP-1RAs had a neutral effect on the composite cardiovascular outcomes but reduced composite kidney events in the patients with advanced DKD compared with DPP-4is.

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The weight maintaining effect of GLP-1RAs may be mediated by smaller decrease in free leptin and higher PYY336 response

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Find out why Lithium remains the first-line bipolar medication, how combining it with Lamotrigine often offers robust mood stabilization, and why regulating sleep is critical for effective bipolar management.