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If you do not have a BMI over 35 but have a BMI over 30 and either have heart failure with preserved ejection fraction, chronic kidney disease stage three A or above, uncontrolled high blood pressure on two or more anti-hypertensive agents, then you qualify

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Article PubMed Google Scholar Mingrone, G

The goal is finding the dose and delivery method that gives you meaningful weight loss results while keeping side effects manageableno patient should feel forced to choose between their health goals and gastrointestinal comfort

This widespread receptor distribution has prompted investigation into potential pleiotropic effects, including anti-inflammatory properties that may contribute to their broader clinical benefits in cardiometabolic disease
