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In addition, the adoption of continuous glucose monitoring systems (CGMS) has risen significantly in the past few years [64, 65]

Unlike approved agents such as semaglutide or tirzepatide, retatrutide's broader receptor activity particularly its glucagon component may produce a more pronounced chronotropic effect

It found a substantially increased risk of deep vein thrombosis (DVT) for patients taking semaglutide drugs to treat type 2 diabetes

Titrating the dose slowly reduces the risk of these side effects

On January 5, 2026, Novo Nordisk introduced oral Wegovy (semaglutide), marking the first FDA-approved oral GLP-1 therapy for chronic weight management, offering a daily pill alternative to weekly injections

McIntyre RS, Mansur RB, Rosenblat JD, Rhee TG, Cao B, Teopiz KM, et al