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Research Evidence Comparison# Retatrutide Research# Phase 1 : First-in-human study established safety and pharmacokinetics Phase 2 (n=338) : Published in NEJM (2023), demonstrated dose-dependent weight loss up to 24.2% at 48 weeks with 12 mg dose

54,55 By doing so, the resulting product has a higher similarity or homology to the amino acid sequence of human GLP-1

Ji L, Onishi Y, Ahn CW, et al

Back Helmholz-Munich (2023) 'Interview: reversing obesity with multi-receptor drugs'

Coadministration of cagrilintide and semaglutide (CagriSema) at 2.4 mg each, once weekly, provides substantial benefits for patients with overweight, obesity, or T2DM