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Discontinuing GLP-1 receptor agonist therapy leads to predictable physiological changes as drug levels decline and the pharmacological effects diminish

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Pathophysiology of GLP-1 therapy induced nausea and vomiting GLP-1 receptor agonists cause nausea and vomiting mainly by binding GLP-1 receptors in the dorsal vagal complex (DVC), a specific vomiting and nausea control center in the brainstem