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Titration Discipline Titration: the path to clinical balance

Starting with Metformin and adding an SGLT2 inhibitor or a GLP-1 agonist allows you to hit your A1C target while protecting your heart and managing weight

Last reviewed: June 17, 2026 Last updated: June 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Here is a realistic breakdown of outcomes: Best responders (~20% of patients): Weight loss of 46 kg over the first year

This daily oral weight loss medicine can be used to suppress your appetite by deceasing your desire to eat and help you feel fuller for longer

Employers should cover all evidence-based obesity care options, including drugs, nutrition therapy, behavioral health services and surgery, the groups say