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Patients with genetic variants suggesting high GLP-1 receptor sensitivity might achieve excellent results at 0.5 mg, while others with reduced sensitivity may advance more aggressively toward 1.7 mg doses

Side Effects Compared With Other GLP-1 Drugs The side effects reported in retatrutide trials are similar to those seen with other GLP-1-based drugs, but some studies suggest they may occur more frequently at higher doses

Notable Harms The frequency of GI disorders was higher in the SEM group, compared with placebo, or active comparator which was not a GLP-1 receptor agonist, such as SIT or insulin (Table 48, Table 49 and Table 50)

If you are planning pregnancy or have become pregnant whilst taking Wegovy, you should inform your GP immediately, as semaglutide is not recommended during pregnancy and should be discontinued at least two months before conception attempts

Compared with placebo, retatrutide treatment resulted in average weight reduction ranging from 7.2% in the lowest dose group to 17.5% in the highest

Other Most Common Side Effects of Wegovy While heartburn is one of the less frequent digestive side effects, healthcare providers should be familiar with the broader safety profile of Wegovy