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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of medications originally developed for type 2 diabetes and, more recently, obesity treatment

GLP-1's are typically prescribed to overweight or obese individuals for whom diet and exercise alone are not effective

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Firstly, peptide drugs encounter digestion by enzymes in the oral cavity, stomach and intestines, which break down the peptides into smaller molecules, resulting in loss or reduction of their activity, requiring frequent administration

Most supplements add minimal benefit when using prescription medications but may cause unnecessary expense or side effects

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