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www.nejm.org/doi/full/10.1056/NEJMoa2032183.

Engages GLP-1 receptors in the hypothalamus and hindbrain to reduce hunger, increase satiety, and lower overall energy intake the primary driver of the weight reduction observed in the STEP trial program

(2002) Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats

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Growing evidence from observational studies indicates that treatment of obesity with bariatric surgery improves cardiovascular outcomes, but these findings have not been confirmed in randomized trials, largely because of randomization challenges with bariatric surgery