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Unlike older weight loss medications that act only in the brain or liver, semaglutide's effects are widespread because GLP-1 receptors exist in multiple organ systems

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Also pause berberine when starting a new CYP450-sensitive medication until drug interactions can be assessed

This compares to a cost effectiveness ratio of $110,000 per QALY gained for a weekly semaglutide injection

It works by mimicking two hormones naturally produced by the body that reduce appetite, slow digestion and lower blood sugar

After eating, your body releases the hormone GLP-1, which does the following: Stimulates Insulin Release : GLP-1 signals the pancreas to release insulin, which helps move sugar from your blood into your cells for energy