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Cardiometabolic benefits: At 48 weeks, improvements included triglyceride reductions up to 40.6% and apoC-III reductions of 38%, along with substantial weight loss (24%) Post-hoc analysis uncovered reductions in albuminuria (3037%) and increased eGFR (8.5 mL/min/1.73 m), suggesting potential kidney-protective effects TRIUMPH-3 and TRIUMPH-OUTCOMES are ongoing Phase 3 studies targeting Cardiovascular safety and outcomes and Renal function in obese individuals with ASCVD or CKD Future with Other GLP-1 and GIP Analogues (Poly-agonists) The development of multi-receptor agonists like retatrutide is the next-generation leap beyond GLP-1 monotherapy, holding potential efficacy comparable to bariatric surgery with fewer GI limitations

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Following our previously reported protocols with the NanoBiT tethering strategy 11 , the structures of retatrutideGLP-1RG s , retatrutideGIPRG s and retatrutideGCGRG s were determined using the single-particle cryo-EM with overall resolutions of 2.68 , 3.26 and 2.84 , respectively (Fig