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Figure 2 Importantly, in the SELECT trial, differences in rates of cardiovascular events between semaglutide and placebo began to emerge within the first few months suggesting that weight loss alone may not account for the full benefits ( On the co-morbidities front, GLP-1R is not expressed in the liver and the data generated with semaglutide in NASH patients seems to support a lack of a direct antifibrotic effect (152)
Take two (2) capsules daily with food and 68 oz of water
Other side effects may include dizziness, headaches, and mild tachycardia (increased heart rate)
The clearest contraindications in the FDA labeling are a personal or family history of medullary thyroid carcinoma (MTC), the genetic condition MEN 2, and a known serious allergic reaction to the specific drug
Your first step is discussing exercise with your physician
Protein, fibre, and other nutrients like potassium, calcium, sodium, and particular vitamins also align with eating less, but not quite as much
