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The initial symptoms may be excessive blinking with progression to more forceful and frequent muscle contraction

Gain-of-function mutations of fem-3, a sex-determination gene in Caenorhabditis elegans

Changes to your diet: Stick to foods that provide the right amount of calories for your weight, height, activity level, and medical status in a way that fills you up

May take longer to work with food

However, one study demonstrated that central administration of an antibody-based GIPR antagonist remarkably decreased body weight in DIO mice, potentially through mechanisms that include restoration of leptin sensitivity (185)