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Individuals who may warrant closer monitoring include: Those with a personal or family history of depression , anxiety, or other mood disorders People who have previously experienced mood changes on other weight-loss medications or GLP-1-based therapies Individuals with eating disorders or a complex relationship with food , for whom appetite suppression may have psychological implications (see NICE guideline NG69: Eating disorders: recognition and treatment) [10] Those experiencing significant life stressors alongside starting a new treatment People with poorly controlled type 2 diabetes , where fluctuating blood glucose levels both hypoglycaemia and hyperglycaemia can independently affect mood, concentration, and emotional wellbeing It is also worth acknowledging that obesity itself is associated with higher rates of depression and anxiety, and that the psychological experience of rapid body weight change whether positive or negative can be emotionally complex

Animal studies consistently show it accelerates healing of ligaments, tendons, and the gut liningSource: Sikiric et al., Curr Pharm Des , 2011

Regarding the latter resolution, this paper introduced the use of GLP-1RAsa drug class traditionally used in the treatment and management of T2DM and obesityas a potential avenue for the treatment of neurodegenerative diseases and neuropathologic conditions alike due to the drugs extensively cited neuroprotective effects

Gudbjrnsdottir et al

However, at higher doses or in the presence of oxidative stress and transition metals, curcumin can also interfere with COX-1 activity

Minor side effects often happen when starting the program but usually fade over time