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Keywords: adenosine monophosphate-activated protein kinase, type 2 diabetes, insulin resistance, drug therapy Introduction Obesity, type 2 diabetes (T2D), and metabolic syndrome have reached epidemic proportions worldwide and the prevalence of these conditions continues to grow

Its also FDA-approved to reduce the risk of major cardiovascular events , such as heart attack and stroke, and to lower the risk of worsening kidney disease in certain patients with type 2 diabetes

Albeit infrequent, severe gastrointestinal complications, such as pancreatitis and bowel obstruction, have also been described

These medications work by slowing gastric emptying, which helps regulate blood sugar levels and promotes a feeling of fullness

For actuaries, these early utilization and discontinuation trends highlight both the scale of the GLP-1 medication adoption and the uncertainty surrounding its long-term financial and health impact

This medication has been developed for the treatment of type 2 diabetes due to its comprehensive effects in regulating appetite, reducing food intake, and improving glycemic control