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Keywords: GLP-1 receptor agonists, type 2 diabetes mellitus, gastrointestinal adverse events, Bayesian network meta-analysis, nausea, vomiting, diarrhea 1 Introduction According to the International Diabetes Federation, the global population with diabetes reached 537 million by 2021, with 90% of cases attributed to type 2 diabetes (T2DM) (Ahmad et al., 2022)

But they have different approved uses

Some patients may theoretically experience changes in intestinal secretions or sensitivity as the digestive system adapts to the medication, though this mechanism remains speculative without specific clinical evidence

Patient Education Is Critical While therapies are effective, adherence can be undermined by side effects or unrealistic expectations

Nothing dramatic

My doctor hasnt totally ruled out that osteoarthritis might be the cause of the damage to my lower back, but the pain there seems very tied to my RA symptoms