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10.1523/JNEUROSCI.23-07-02939.2003 [DOI] [PMC free article] [PubMed] [Google Scholar] Yamamoto, T

Safety studies have evaluated single doses up to 0.4 grams per kilogram of body weight (approximately 28 grams for a 70-kilogram adult) without serious adverse effects, though gastrointestinal symptoms represent the primary tolerability concern

NEW - Blue Shield will launch three PPO Savings Plans offering expanded weight loss drug coverage in 2027: Full PPO Savings Embedded Deductible 3400 100% with Enhanced+ Rx Full PPO Savings Two-Tier Embedded Deductible 1700/3400/3400 90/60 with Enhanced+ Rx NOTE: Weight loss drugs under these plans are covered with prior authorization for BMI 30 or 27 with certain weight-related conditions, lowering the requirement from the previous BMI of 40

PlexusDx Microdose GLP-1 Protocol ($129/mo) offers a gentler entry point designed to minimize rapid weight loss shocks while still producing meaningful results

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For branded products approved to reduce weight in obesity, some also have expanded use to younger patients, and/or additional at-risk adult populations