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According to clinical trial data from the SURPASS studies , the most frequently reported side effects include: Nausea Vomiting Diarrhea Decreased appetite Constipation While gastrointestinal side effects are the most common, there are reports of headaches in some patients

Dylan Belmont-Rausch1, MartJimnezMausbach1, JanChristianRefsgaard1,GabrielMartino1,TeresaLeonColombo1,BettyTijms2,ClarePaterson3

The treatment plan may need medical review or adjustment rather than continued guesswork

GIP has long been known for its role in insulin release after meals

They amplify the insulin sensitivity of peripheral tissues while reducing glucose synthesis in the liver, but they can also result in fluid retention, potentially worsening heart failure