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Mounjaro dosing schedule The tirzepatide dosing protocol is well-established through FDA-approved labeling: Week 1-4: 2.5 mg once weekly (starter dose, not a maintenance dose) Week 5-8: 5 mg once weekly Week 9-12: 7.5 mg once weekly Week 13-16: 10 mg once weekly Week 17-20: 12.5 mg once weekly Week 21+: 15 mg once weekly (maximum dose) Dose increases occur in 2.5 mg increments every four weeks