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The GIP pathway was historically considered less pharmacologically useful than GLP-1 because early work suggested the receptor became less responsive in metabolic-disease states

( : The New England Journal of Medicine) [ ] GLP-1

Others have reported nausea, vomiting, extreme stomach cramps and have had to seek hospital treatment

Anxiety wasnt a side effect in semaglutide clinical trials

Semaglutide's appetite-suppressing effects can make fasting periods easier to manage, while intermittent fasting can further enhance the caloric deficit needed for weight loss

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