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Programs are not gone - but the environment is shifting

Once insulin crosses the BBB, it binds to IRs located on neurons and glial cells, allowing it to act as a neuromodulator rather than just a metabolic hormone
GLP-1 modulates fat lipid metabolism Fat synthesis includes three aspects: de novo synthesis of saturated fatty acids, extension of fatty acid carbon chains, and synthesis of unsaturated fatty acids

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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, et al