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Manual Therapy: This includes hands-on techniques like massage and mobilization
As the placebo group continued to have an increasing (worsening) motor score over time, the exenatide-treated group demonstrated improvements, which remarkably remained after the treatment had been stopped for 3 months (weeks 48-60 on the graph below)

FIGURE 2 3.2 GLP-1 improves cognition by regulating the oxidative metabolic pathway of cells Oxidative stress refers to an imbalance in free radicals and the cellular antioxidant defense system in favor of the formation of free radicals (Yaribeygi et al., 2020b
Because obesity is considered a long-term, relapsing metabolic condition, ongoing treatment is often necessary to maintain results

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Fifth, hormonal measurements were performed while patients remained on semaglutide, which may have influenced endogenous GLP-1 levels through feedback inhibition (in one sample)
