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GLP-1 is a naturally occurring hormone involved in appetite signaling and digestion

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Among these effects, increased insulin sensitivity, either by direct action on target organs or secondary to weight loss, might act synergistically with enhanced beta-cell function and insulin upregulation in the pancreas, collectively improving metabolic control.

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Repatha is used to lower high cholesterol alongside dietary changes and to reduce the risk of major cardiovascular events in those at increased risk for these events, such as death from cardiovascular disease, heart attack, stroke, angina requiring hospitalization, or certain types of heart surgery