contraindications for glp-1 agonists include Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Receptor Agonists: A Multidisciplinary Expert Consensus Adverse Effects of GLP-1 Receptor

Notably, the US FDA submission documents for tirzepatide include predictions of DDIs mediated by delayed gastric emptying using PBPK modeling, rather than conducting clinical DDI studies for certain drugs (Table 6)

58 Studies have demonstrated that therapy involving teneligliptin activates AMPK pathway responses while curbing the expression of genes linked to lipogenesis, thereby ameliorating nonalcoholic fatty liver disease observed within mouse models

PLoS One, 18 (8), e0289616

Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium

Neuropeptides (2018) 71:7080

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms