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This dual mechanism appears to produce even greater effects on blood sugar and body weight than GLP-1-only medications
In line with our short-term metabolic analyses, previous studies in New Zealand obese and diet-induced obese male mice suggested that GLP1/E acts primarily at central levels to reverse metabolic alterations by decreasing food intake and body weight, while the potential beneficial effects on pancreatic beta-cells were possibly secondary and indirectly-mediated 33,48

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This case demonstrates that prolonged water fasting with concurrent GLP-1 use is likely both effective and safe for the purpose of short-term weight reduction as a bridge to bariatric surgery

That 10% difference sounds small until you realize it translates to preserving an extra 1-2 kg of lean tissue over a typical weight loss period