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For key continuous outcomes, 95% confidence intervals were estimated using bootstrap resampling due to the limited sample size

These agents are also associated with a minimal risk of hypoglycemia when used as monotherapy or as add-on to metformin monotherapy, but they can contribute to hypoglycemia when used in combination with medications associated with hypoglycemia, such as insulin and insulin secretagogues

A large number of GLP-1/Ex4 chimaeric peptides have been utilized in order to understand the determinants that enable Ex4(9-39) to retain potent antagonist activity, while GLP-1(15-36) remains an agonist (Patterson et al ., 2011b)

GLP-1 RAs: Clinical Primer GLP-1 is a regulatory hormone derived from the proglucagon gene and secreted in response to food consumption

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Messer are skeptical that the compounds could have the same effects as the synthetic versions