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Umbareen Mahmood, MD, a board-certified plastic surgeon in New York City, says shes now even encountering men and women with already-low BMIs who are using the drugs to lose a few pounds for a big event or beach vacation. Surprisingly, many of these patients are still seeing negative aesthetic side effects, likely due to how rapid the weight loss wasthose who lose weight gradually tend to have better tissue elasticity and skin retractionand also because their margin for loss is smaller given that they were already at a healthy weight for their body. (When someones BMI is low to start, she explains, losing a few pounds can have a significant impact on the little bit of fat you have.) Jerry Chidester, MD, a board-certified plastic surgeon in Draper, Utah, tells me that close to half of his patients are currently using a GLP-1 or have in the past

doi: 10.1016/j.ejphar.2016.10.016 [DOI] [PubMed] [Google Scholar] 153

Whatever the reason, the clinical development program ended

But her symptoms worsened

These drugs help control blood sugar and reduce appetite, and clinical trials have shown they can lead to weight losses of 15 to 20%

Unopened GLP-1 pens typically remain stable in the fridge at 28C until their printed expiry date, whilst opened multi-dose pens have specific in-use periods ranging from 30 days to 6 weeks depending on the product
